Rifaximin 400mg | JEPRIFA-400

Rifaximin 400 mg Tablets – A broad-spectrum antibiotic primarily which is used to treat bacterial infections of the gastrointestinal tract. Belonging to the rifamycin class of antibiotics and working locally within the intestines with minimal absorption into the bloodstream. 

Therefore, it makes Rifaximin a highly effective option in managing intestinal bacterial infections while reducing the risk of systemic side effects. It is commonly prescribed for conditions such as traveller’s diarrhoea, hepatic encephalopathy, and irritable bowel syndrome with diarrhoea. The medication helps restore normal intestinal bacterial balance and improves digestive health.

The medication reduces harmful bacteria responsible for infection, inflammation, and toxin production without significantly affecting other parts of the body. When taken as prescribed, it helps relieve symptoms such as diarrhoea, bloating, abdominal discomfort, and excessive bacterial growth in the intestines. Rifaximin Tablet is manufactured by Snaify Healthcare under the brand name JEPRIFA-400. 

Explanation: Working Mechanism of Rifaximin 400 mg Tablets

The Working Mechanism has been explained as follows:

Rifaximin is a non-systemic antibiotic that exerts its antibacterial action locally within the gastrointestinal tract. The drug works by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase. Hence, by inhibiting this enzyme, Rifaximin prevents bacteria from producing proteins necessary for their growth, survival, and reproduction. 

As bacterial protein synthesis stops, the bacteria are unable to multiply and eventually die.

Benefits of Rifaximin Tablets: How it Offers Advantageous Benefits 

The Benefits of using Rifaximin Tablets are as follows:

Helps Treat Intestinal Bacterial Infections – Rifaximin works directly in the intestines to control harmful bacteria, helping relieve infection-related symptoms such as diarrhoea, stomach discomfort, and digestive irritation.

Provides Relief from Traveller’s Diarrhoea – It helps treat traveller’s diarrhoea caused by certain bacteria, reducing frequent loose stools, easing abdominal cramps, and supporting a quicker recovery.

Supports People with IBS-D – Rifaximin helps manage symptoms of irritable bowel syndrome with diarrhoea by reducing bloating, stomach pain, and frequent bowel movements, improving daily comfort.

Reduces the Risk of Hepatic Encephalopathy – For people with liver disease, Rifaximin helps lower toxin-producing bacteria in the gut, reducing the chances of recurrent hepatic encephalopathy episodes.

Works Directly in the Gut – Unlike many antibiotics, Rifaximin acts mainly in the intestines with minimal absorption into the bloodstream, allowing targeted treatment with fewer body-wide effects. 

Uses of Rifaximin Tablets

Rifaximin Tablets are commonly used for:

• Traveller’s diarrhoea caused by susceptible bacteria.
• Hepatic encephalopathy.
• Irritable bowel syndrome with diarrhoea.
• Small intestinal bacterial overgrowth (SIBO).
• Other gastrointestinal bacterial infections.

How to Take Rifaximin Tablets? Guidelines 

The instructions are as follows: 

• Take the tablet exactly as prescribed by your doctor.
• Swallow the tablet whole; do not crush, chew, or break the tablet.
• Take the medicine at the same time every day.

Side Effects of Rifaximin Tablets

Like all medicines, Rifaximin may cause side effects, although not everyone experiences them.

• Nausea.
• Abdominal pain.
• Bloating.
• Flatulence.
• Headache.

Safety Measures and Precautions: Rifaximin Tablets

While taking the Rifaximin Tablets, a few safety measures and precautions have to be followed, which will help in decreasing adverse side effects.  

• Use Rifaximin Tablets only under the supervision of a qualified healthcare professional.
• Complete the full course of antibiotic therapy.
• Inform your doctor if you have severe liver disease.
• Inform your healthcare provider about all medicines you are currently taking.
• Contact your doctor if diarrhoea persists or worsens after treatment.

Storage Instructions

To store Rifaximin Tablets, follow the instructions: 

• Store below 25°C in a cool and dry place.
• Protect the tablets from moisture.
• Keep the Rifaximin Tablets away from direct sunlight. 
• Keep out of reach of pets and children.
• Avoid freezing the tablets.